| http://purl.uniprot.org/citations/7717687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7717687 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain-derived neurotrophic factor (BDNF) has been shown to promote the survival of developing motor neurons in vitro and to rescue motor neurons from axotomy-induced cell death in vivo. In this study, we examined the effects of exogenous BDNF on the progression of wobbler mouse motor neuron disease (MND). After clinical diagnosis at age 3 to 4 weeks, 20 affected mice received subcutaneous injections of recombinant human BDNF (5 mg/kg, n = 10) or vehicle (n = 10), three times a week for 4 weeks. In a separate experiment done to conduct a histometric analysis of the C-5 and C-6 ventral roots and to determine the number of myelinated nerve fibers, 7 wobbler mice received identical BDNF treatment. In the 10 BDNF-treated wobbler mice, grip strength declined at a slower rate (p < 0.03) and was twice as great as that of vehicle-treated animals at the end of treatment (p < 0.01). In vivo biceps (p < 0.01) and in vitro muscle twitch tensions (p < 0.02) were also greater than those of vehicle-treated mice. The biceps muscle weight was 20% greater (p < 0.05) and the mean muscle fiber diameter was significantly larger in BDNF-treated mice (p < 0.001) because the number of small (denervated) muscle fibers was markedly reduced. The number of myelinated motor axons at the cervical ventral roots studied in the additional 7 affected mice was 25% greater with BDNF treatment (p < 0.0001). This study establishes that exogenous BDNF administration can retard motor dysfunction in a natural MND and diminish denervation muscle atrophy and motor axon loss."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.org/dc/terms/identifier | "doi:10.1002/ana.410370413"xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/author | "Ikeda K."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/author | "Wong V."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/author | "Lindsay R.M."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/author | "Mitsumoto H."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/author | "Greene T."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/author | "Cedarbaum J.M."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/author | "Klinkosz B."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/name | "Ann Neurol"xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/pages | "505-511"xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/title | "Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease."xsd:string |
| http://purl.uniprot.org/citations/7717687 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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