| http://purl.uniprot.org/citations/7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7718892 | http://www.w3.org/2000/01/rdf-schema#comment | "To assess the functional capacity of the heterogeneous Fc gamma RII (CD32) family and to identify critical regions for functioning, we generated a panel of B-cell transfectants. The Fc gamma R-negative B-cell line IIA1.6 was transfected with wild-type or mutant human Fc gamma RIIa and IIb molecules. Solely Fc gamma RIIa-expressing IIA1.6 cells were capable of phagocytosing opsonized Staphylococcus aureus bacteria, and cross-linking of Fc gamma RIIa triggered a rapid induction of tyrosine phosphorylation after 20 seconds. Analysis of Fc gamma RIIa mutants identified the immunoreceptor tyrosine-based activation motif (ITAM; previously described as ARH-1 motif) within the IIa cytoplasmic tail to be critical for B-cell activation. In contrast, Fc gamma RIIb isoforms triggered tyrosine phosphorylation on cross-linking with much slower kinetics (> 3 minutes) than Fc gamma RIIa. Furthermore, solely Fc gamma RIIb molecules proved capable of downregulating [Ca2+]i and interleukin-2 production on co-cross-linking with sIgG in IIA1.6. The Fc gamma RIIb-mediated functions were absent in Fc gamma RIIb mutants in which the tyrosine or leucine within the YSLL motif in a conserved 13-aa region (now known as immunoreceptor tyrosine-based inhibitor motif [ITIM]) were changed into phenylalanines. In conclusion, these data show the presence of functionally critical motifs within Fc gamma RII cytoplasmic tails. Fc gamma RIIa contains an ITAM involved in B-cell activatory functions, whereas the downregulatory activity of Fc gamma RIIb isoforms is linked to an ITIM."xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/author | "Capel P.J."xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/author | "Van de Winkel J.G."xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/author | "Van den Herik-Oudijk I.E."xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/author | "van der Bruggen T."xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/pages | "2202-2211"xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/title | "Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms."xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/7718892 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7718892 |
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| http://purl.uniprot.org/uniprot/#_A0A0C4DH25-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH73-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_A0A075B6P5-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_A0A075B6S6-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_P0CF74-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_P0CG04-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_A2KUC3-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_A2NJV5-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_A2NXD2-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_A0M8Q6-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_P04211-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |
| http://purl.uniprot.org/uniprot/#_P06310-mappedCitation-7718892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7718892 |