| http://purl.uniprot.org/citations/7722444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7722444 | http://www.w3.org/2000/01/rdf-schema#comment | "The differentiation potential of putative intermediates between CD4+8+ thymocytes and mature T cells has been examined. Such intermediate populations were sorted, in parallel with CD4+8+ thymocytes, from three types of C57BL/6 mice: major histocompatibility complex (MHC) class II-deficient mice, mice transgenic for an alpha/beta T cell receptor (TCR) restricted by class I MHC and normal mice. The sorted populations were then transferred into the thymus of nonirradiated C57BL/Ka mice differing in Thy 1 allotype, and the progeny of the transferred cells were analyzed 2 d later. Surprisingly, with all three types of donor mice, a major proportion of the CD4+8intTCRint-derived progeny were found to be CD4-8+TCRhi cells, thus delineating a new alternative pathway for development of the CD8 lineage. In contrast, the transfer of CD4int8+TCRint thymocytes produced CD4-8+TCRhi cells but no significant proportion of CD4+8-TCRhi cells, suggesting that there is no equivalent alternative pathway for the CD4 lineage. The results negate some of the evidence for a stochastic/selective model of lineage commitment, and point to an asymmetry in the steps leading to CD4-8+ versus CD4+8- T cells."xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.181.5.1643"xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/author | "Lundberg K."xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/author | "Carbone F.R."xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/author | "Shortman K."xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/author | "Kontgen F."xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/author | "Heath W."xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/pages | "1643-1651"xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/title | "Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes."xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/7722444 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7722444 |
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| http://purl.uniprot.org/uniprot/#_P01910-mappedCitation-7722444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7722444 |
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