| http://purl.uniprot.org/citations/7724549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7724549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7724549 | http://www.w3.org/2000/01/rdf-schema#comment | "EBNA 2 (Epstein-Barr virus nuclear antigen 2) is an acidic transactivator essential for EBV transformation of B lymphocytes. We show that EBNA 2 directly interacts with general transcription factor IIH. Glutathione S-transferase (GST)-EBNA 2 acidic domain fusion protein depleted transcription factor IIH activity from a TFIIH nuclear fraction. The p89 (ERCC3), p80 (ERCC2), and p62 subunits of TFIIH were among the proteins retained by GST-EBNA 2. Eluates from the GST-EBNA 2 beads reconstituted activity in a TFIIH-dependent in vitro transcription assay. The p62 and p80 subunits of TFIIH independently bound to GST-EBNA 2, whereas the p34 subunit of TFIIH only bound in the presence of p62. A Trp-->Thr mutation in the EBNA 2 acidic domain abolishes EBNA 2 transactivation in vivo and greatly compromised EBNA 2 association with TFIIH activity and with the p62 and p80 subunits, providing a link between EBNA 2 transactivation and these interactions. Antibodies directed against the p62 subunit of TFIIH coimmunoprecipitated EBNA 2 from EBV-transformed B lymphocytes, indicating that EBNA 2 associates with TFIIH in vivo."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.8.3259"xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.8.3259"xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Kieff E."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Kieff E."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Drapkin R."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Drapkin R."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Tong X."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/author | "Tong X."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/pages | "3259-3263"xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/pages | "3259-3263"xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/title | "The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/title | "The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2."xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/7724549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7724549 |
| http://purl.uniprot.org/citations/7724549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7724549 |