| http://purl.uniprot.org/citations/7724703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7724703 | http://www.w3.org/2000/01/rdf-schema#comment | "Among inbred mice, genetic factors mediate differences in sensitivity to the convulsant properties of cocaine; however, the gene(s) underlying cocaine's effects have not been identified. To help elucidate the gene(s) responsible for cocaine seizure susceptibility, we used recombinant inbred-quantitative trait loci (RI-QTL) analyses to identify chromosomal loci associated with cocaine-induced seizures. RI-QTL analyses seek to identify associations between a quantitative measure of a particular phenotype and one or more previously mapped marker genes across a panel of RI strains. This report describes an RI-QTL analysis of cocaine seizure susceptibility among 26 BXD RI strains. These strains showed a skewed, bimodal range of seizure susceptibility which could be the result of one or more modifying genes acting in concert with a major gene to influence cocaine sensitivity. Correlating the percent seizures displayed by each strain following 60 mg/kg cocaine with chromosomal marker data for these strains revealed a number of significant correlations clustered in two regions on chromosomes 12 and 6. This is the first identification of putative chromosomal loci associated with a cocaine-related phenotype and should facilitate identification of the gene(s) underlying cocaine toxicity and other cocaine-related phenotypes."xsd:string |
| http://purl.uniprot.org/citations/7724703 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf02245099"xsd:string |
| http://purl.uniprot.org/citations/7724703 | http://purl.uniprot.org/core/author | "Miner L.L."xsd:string |
| http://purl.uniprot.org/citations/7724703 | http://purl.uniprot.org/core/author | "Marley R.J."xsd:string |
| http://purl.uniprot.org/citations/7724703 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7724703 | http://purl.uniprot.org/core/name | "Psychopharmacology (Berl)"xsd:string |
| http://purl.uniprot.org/citations/7724703 | http://purl.uniprot.org/core/pages | "62-66"xsd:string |
| http://purl.uniprot.org/citations/7724703 | http://purl.uniprot.org/core/title | "Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice."xsd:string |
| http://purl.uniprot.org/citations/7724703 | http://purl.uniprot.org/core/volume | "117"xsd:string |
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