| http://purl.uniprot.org/citations/7729684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7729684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7729684 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent kinases (Cdks) are positive regulators of cell proliferation, whereas Cdk inhibitors (CKIs) inhibit proliferation. We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1. p57KIP2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Unlike CIP1, KIP2 is not regulated by p53. Overexpression of p57KIP2 arrests cells in G1. p57KIP2 proteins have a complex structure. Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1. Human p57KIP2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. In situ hybridization during mouse embryogenesis revealed that KIP2 mRNA displays a striking pattern of expression during development, showing high level expression in skeletal muscle, brain, heart, lungs, and eye. Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57KIP2 is involved in decisions to exit the cell cycle during development and differentiation. Human KIP2 is located at 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, marking it as a candidate tumor suppressor. The discovery of a new member of the p21CIP1 inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.9.6.650"xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.9.6.650"xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Matsuoka S."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Matsuoka S."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Bai C."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Bai C."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Baldini A."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Baldini A."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Parker S."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Parker S."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Edwards M.C."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/author | "Edwards M.C."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/7729684 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |