| http://purl.uniprot.org/citations/7744246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7744246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7744246 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear receptor superfamily. LXR alpha shows a specific pattern of expression in visceral organs, thereby restricting the response to certain tissues. Retinoid trans-activation occurs selectively on a distinct response element termed an LXRE. Significantly, neither RXR homodimers nor RXR/RAR heterodimers are able to substitute for LXR alpha in mediating this retinoid response. We provide evidence that the retinoid response on the LXRE is the result of a unique interaction between LXR alpha and endogenous RXR, which, unlike in the RXR/RAR heterodimer, makes RXR competent to respond to retinoids. Thus, the interaction with LXR alpha shifts RXR from its role described previously as a silent, DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXREs."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.9.9.1033"xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.9.9.1033"xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Umesono K."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Umesono K."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Mangelsdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Mangelsdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Ong E.S."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Ong E.S."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Heyman R.A."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Heyman R.A."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Willy P.J."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/author | "Willy P.J."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/pages | "1033-1045"xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/pages | "1033-1045"xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/title | "LXR, a nuclear receptor that defines a distinct retinoid response pathway."xsd:string |
| http://purl.uniprot.org/citations/7744246 | http://purl.uniprot.org/core/title | "LXR, a nuclear receptor that defines a distinct retinoid response pathway."xsd:string |