| http://purl.uniprot.org/citations/7748564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7748564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7748564 | http://www.w3.org/2000/01/rdf-schema#comment | "REK7 is an Eph-related tyrosine kinase receptor expressed exclusively in the nervous system, predominantly in hippocampus and cortex. A soluble REK7-IgG fusion protein, produced to analyze the biological role of REK7, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. Using REK7-IgG as an affinity reagent, we purified and cloned a novel REK7 ligand called AL-1, a GPI-linked protein homologous to other members of an emerging ligand family. Membrane attachment of AL-1 appears necessary for receptor activation, since REK7 on cortical neurons is efficiently activated by transfected cells expressing GPI-linked AL-1, but not by soluble AL-1. Consistent with this, soluble AL-1 blocks axon bundling. Our findings, together with the observation that both molecules are expressed in the brain, suggest a role in the formation of neuronal pathways, a crucial feature of nervous system development and regeneration."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.org/dc/terms/identifier | "doi:10.1016/0896-6273(95)90335-6"xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.org/dc/terms/identifier | "doi:10.1016/0896-6273(95)90335-6"xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Moran P."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Moran P."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Winslow J.W."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Winslow J.W."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Goddard A."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Goddard A."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Henzel W.J."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Henzel W.J."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Wong S.C."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Wong S.C."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Tsai S.P."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Tsai S.P."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Caras I.W."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Caras I.W."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Beck K.D."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Beck K.D."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Hefti F."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Hefti F."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Shih A."xsd:string |
| http://purl.uniprot.org/citations/7748564 | http://purl.uniprot.org/core/author | "Shih A."xsd:string |