| http://purl.uniprot.org/citations/7753802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7753802 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have implicated the bcl-2 protooncogene as a potential regulator of neuronal survival. However, mice lacking functional bcl-2 exhibited normal development and maintenance of the central nervous system (CNS). Since bcl-2 appears dispensable for neuronal survival, we have examined the expression and function of bcl-x, another member of the bcl-2 family of death regulatory genes. Bcl-2 is expressed in neuronal tissues during embryonic development but is down-regulated in the adult CNS. In contrast, Bcl-xL expression is retained in neurons of the adult CNS. Two different forms of bcl-x mRNA and their corresponding products, Bcl-xL and Bcl-x beta, were expressed in embryonic and adult neurons of the CNS. Microinjection of bcl-xL and bcl-x beta cDNAs into primary sympathetic neurons inhibited their death induced by nerve growth factor withdrawal. Thus, Bcl-x proteins appear to play an important role in the regulation of neuronal survival in the adult CNS."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.10.4304"xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/author | "Gonzalez-Garcia M."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/author | "O'Shea S."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/author | "Garcia I."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/author | "Boise L.H."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/pages | "4304-4308"xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/title | "bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death."xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/7753802 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7753802 |
| http://purl.uniprot.org/citations/7753802 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7753802 |
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