| http://purl.uniprot.org/citations/7753825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7753825 | http://www.w3.org/2000/01/rdf-schema#comment | "We have ectopically expressed transcription factor ETS1 in two different highly tumorigenic human colon cancer cell lines, DLD-1 and HCT116, that do not express endogenous ETS1 protein and have obtained several independent clones. The expression of wild-type ETS1 protein in these colon cancer cells reverses the transformed phenotype and tumorigenicity in a dose-dependent manner. By contrast, expression in DLD-1 cells of a variant form of ETS1, lacking transcriptional activity, did not alter the tumorigenic properties of the cells, suggesting that the reduction in tumorigenicity in these clones was specific for the wild-type ETS1 gene products. Since these colon cancer cells have multiple genetic alterations, the system described in this paper could be a good model to study the suppression of tumorigenicity at a transcriptional level, which could lead to the design and development of novel drugs for cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.10.4442"xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/author | "Papas T.S."xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/author | "Romano-Spica V."xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/author | "Bhat N.K."xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/pages | "4442-4446"xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/title | "ETS1 suppresses tumorigenicity of human colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/7753825 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7753825 |
| http://purl.uniprot.org/citations/7753825 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7753825 |
| http://purl.uniprot.org/uniprot/P14921#attribution-694B4E4E1FC05F204F52891FA5FCDDA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7753825 |