| http://purl.uniprot.org/citations/7756448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7756448 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent evidence indicates that a member of the Y box-binding family of transcriptional regulators is identical to p56, a predominant protein of messenger ribonucleoprotein complexes. The p56 protein is highly enriched in oocytes and testis, and a functional RNA binding mouse cytoplasmic homologue has been cloned and partially characterized. Because few potential testis-specific transcriptional regulators have been identified, the testis-enriched Y box-binding proteins represent trans-acting elements of a unique model system for the study of haploid gene expression. The 5' flanking region of the testis-specific, haploid-expressed mouse protamine 2 gene contains an element with a 9-of-12 nucleotide identity with the previously defined Y box consensus sequence. We have investigated the possible role of Y box-binding proteins in transcriptional regulation of protamine 2 using specific antibodies and DNA-protein binding assays. Western blot analyses with two different anti-p54/p56 antibodies demonstrate that a mouse homologue of Xenopus p54/p56 is present in transcriptionally active mouse testis nuclear extracts. Our results further indicate that the Xenopus Y box-binding proteins bind to an element 5' to the mouse protamine 2 gene. Similarly, binding of the mouse testis homologue to the protamine 2 Y box element is demonstrated by gel mobility shift and antibody supershift analyses. The demonstrated interactions between testis-enriched Y box-binding proteins and protamine 2 transcriptional control elements therefore represent a unique system for functional studies to determine the mechanism of regulation of haploid gene expression."xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.org/dc/terms/identifier | "doi:10.1095/biolreprod52.3.524"xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/author | "Hecht N.B."xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/author | "Nikolajczyk B.S."xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/author | "Murray M.T."xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/pages | "524-530"xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/title | "A mouse homologue of the Xenopus germ cell-specific ribonucleic acid/deoxyribonucleic acid-binding proteins p54/p56 interacts with the protamine 2 promoter."xsd:string |
| http://purl.uniprot.org/citations/7756448 | http://purl.uniprot.org/core/volume | "52"xsd:string |
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