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http://purl.uniprot.org/citations/7773929http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7773929http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7773929http://www.w3.org/2000/01/rdf-schema#comment"

Background

The frequency and clinicopathologic significance of the K-ras gene point mutation in stomach cancer remain to be defined.

Methods

The authors investigated the frequency of K-ras codon 12 point mutations in stomach cancer using a sensitive polymerase chain reaction (PCR)-based method in 140 samples and correlated the findings with various clinicopathologic characteristics of the patients.

Results

The overall frequency of K-ras codon 12 point mutations in stomach cancer was 7.9% (11/140). DNA sequencing of nine cases with K-ras codon 12 point mutations identified seven cases with a single-base substitution of GGT to AGT (glycine to serine) and two with single-base substitution of GGT to AGT (aspartic acid). Tumors located in the upper third of the stomach had a significantly higher frequency of K-ras codon 12 mutations (3/8, 37.5%) compared with tumors located in the middle (4/29, 13.8%) or lower (3/99, 3.0%) thirds of the stomach (P = 0.001). No significant difference was observed in the frequency of K-ras codon 12 mutations in terms of other various clinicopathologic characteristics including tumor DNA ploidy and S-phase fraction. After a median follow-up of 26 months, disease free and overall survival were not significantly different between patients with stomach cancer with or without K-ras codon 12 mutation. Among eight patients with stomach cancer located in the upper part of the stomach, none of the three patients with K-ras gene-mutated tumors died versus four of five with tumors without K-ras gene mutations (P = 0.064).

Conclusions

K-ras codon 12 point mutations are uncommon in stomach cancer (7.9%). There was significant correlation between K-ras mutations and vertical tumor location in the stomach, suggesting that different mechanisms may play a role in the pathogenesis of stomach cancer according to the location of tumors in the stomach."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.org/dc/terms/identifier"doi:10.1002/1097-0142(19950615)75:12<2794::aid-cncr2820751203>3.0.co;2-f"xsd:string
http://purl.uniprot.org/citations/7773929http://purl.org/dc/terms/identifier"doi:10.1002/1097-0142(19950615)75:12<2794::aid-cncr2820751203>3.0.co;2-f"xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee J.H."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee J.H."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee M.S."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee M.S."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee J.S."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee J.S."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Kim S.H."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Kim S.H."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee K.H."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Lee K.H."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Kim S.B."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Kim S.B."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Kim S.W."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Kim S.W."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Park M.Y."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Park M.Y."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Sun H.S."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Sun H.S."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Suh C."xsd:string
http://purl.uniprot.org/citations/7773929http://purl.uniprot.org/core/author"Suh C."xsd:string
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