| http://purl.uniprot.org/citations/7782294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7782294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7782294 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-cbl protooncogene product (c-Cbl) is a 120-kDa protein that has been shown to bind to the Src homology 3 domains of various proteins, suggesting its involvement in signal transduction pathways. We identified one of the most prominent tyrosine-phosphorylated proteins in Fc gamma receptor (Fc gamma R)-stimulated macrophages to be c-Cbl. Tyrosine phosphorylation of c-Cbl occurred within 20 s after stimulation and reached maximum levels within 3-5 min. c-Cbl was also tyrosine-phosphorylated in epidermal growth factor (EGF) receptor-overexpressing cells upon EGF stimulation, in macrophages in response to CSF-1 treatment, and in v-src transformed cells. Furthermore, we found that c-Cbl associated with these kinases in vivo. In vitro, c-Cbl bound to the Src homology 3 domains of Src, Fyn, and Lyn in both unstimulated and Fc gamma R-stimulated macrophages. Examination of cells by immunofluorescence revealed that c-Cbl is diffusely distributed in the cytoplasm in both unstimulated macrophages and EGF receptor-overexpressing cells and translocated to a more specific compartment of the cell, consistent with the trans-Golgi region, following Fc gamma R clustering and EGF stimulation, respectively. These results suggest that c-Cbl is involved in the signaling pathways utilized by different types of tyrosine kinases."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.24.14347"xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.24.14347"xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Baron R."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Baron R."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Neff L."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Neff L."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Levy J.B."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/author | "Levy J.B."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/pages | "14347-14351"xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/pages | "14347-14351"xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/title | "Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/title | "Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7782294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7782294 |
| http://purl.uniprot.org/citations/7782294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7782294 |