| http://purl.uniprot.org/citations/7791877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7791877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7791877 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptotagmins (Syts) are brain-specific Ca2+/phospholipid-binding proteins. In hippocampal synapses, Syt I is essential for fast Ca(2+)-dependent synaptic vesicle exocytosis but not for Ca(2+)-independent exocytosis. In vertebrates and invertebrates, Syt may therefore participate in Ca(2+)-dependent synaptic membrane fusion, either by serving as the Ca2+ sensor in the last step of fast Ca(2+)-triggered neurotransmitter release, or by collaborating with an additional Ca2+ sensor. While Syt I binds Ca2+ (refs 10, 11), its phospholipid binding is triggered at lower calcium concentrations (EC50 = 3-6 microM) than those required for exocytosis. Furthermore, Syts bind clathrin-AP2 with high affinity, indicating that they may play a general role in endocytosis rather than being confined to a specialized function in regulated exocytosis. Here we resolve this apparent contradiction by describing four Syts, three of which (Syt VI, VII and VIII) are widely expressed in non-neural tissues. All Syts tested share a common domain structure, with a cytoplasmic region composed of two C2 domains that interacts with clathrin-AP2 (Kd = 0.1-1.0 nM) and with neural and non-neural syntaxins. The first C2 domains of Syt I, II, III, V and VII, but not of IV, VI or VIII, bind phospholipids with a similar Ca(2+)-concentration dependence (EC50 = 3-6 microM). The same C2 domains also bind syntaxin as a function of Ca2+ but the Ca(2+)-concentration dependence of Syt I, II and V (> 200 microM) differs from that of Syt III and VII (< 10 microM).(ABSTRACT TRUNCATED AT 250 WORDS)"xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.org/dc/terms/identifier | "doi:10.1038/375594a0"xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.org/dc/terms/identifier | "doi:10.1038/375594a0"xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Zhang J.Z."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Zhang J.Z."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Anderson R.G.W."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Anderson R.G.W."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Brose N."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Brose N."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Ullrich B."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/author | "Ullrich B."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/pages | "594-599"xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/pages | "594-599"xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/title | "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins."xsd:string |
| http://purl.uniprot.org/citations/7791877 | http://purl.uniprot.org/core/title | "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins."xsd:string |