| http://purl.uniprot.org/citations/7797592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7797592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7797592 | http://www.w3.org/2000/01/rdf-schema#comment | "Cysteine proteases related to mammalian interleukin-1 beta-converting enzyme (ICE) and the nematode cell death abnormal ced-3 gene product have been implicated in the effector mechanism of apoptotic cell death. Two novel members of this new family of ICE/CED-3-related proteases, designated ICErel-II and ICErel-III, were cloned from human monocytic cells. Both were highly homologous to human ICE (52% identical) and CED-3 (25% identical) and both contained the absolutely conserved pentapeptide sequence Gln-Ala-Cys-Arg-Asp containing the catalytic cysteine residue. Other structural motifs that were comparable with ICE suggest that ICErel-II and ICErel-III are also synthesized as larger proenzymes which are proteolytically processed to form heterodimeric active enzymes. Pro-interleukin-1 beta processing activity could not be detected in cells transfected with ICErel-II or ICErel-III, but pro-domain-less truncated forms of ICErel-II and ICErel-III were capable of effectively inducing fibroblast apoptosis. ICErel-II and ICErel-III may, therefore, participate in proteolytic events culminating in the apoptotic death of human cells."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.26.15870"xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.26.15870"xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Ali A."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Ali A."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Nicholson D.W."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Nicholson D.W."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Vaillancourt J.P."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Vaillancourt J.P."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Miller D.K."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Miller D.K."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Yamin T.-T."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Yamin T.-T."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Casano F.J."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Casano F.J."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Molineaux S.M."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Molineaux S.M."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Munday N.A."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Munday N.A."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Yu V.L."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/author | "Yu V.L."xsd:string |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7797592 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |