| http://purl.uniprot.org/citations/7809086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7809086 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify proteins that bind to the Ras-related protein R-ras we performed a yeast two-hybrid cDNA library screen. Several clones were obtained encoding the C-terminal region of the guanine nucleotide dissociation stimulator for Ral (RalGDS). The R-ras-binding domain of RalGDS (RalGDS-RBD) is distinct from the conserved catalytic exchange factor regions. Using the two-hybrid system, we show that RalGDS-RBD interacts with H-ras, K-ras, and Rap, and with active but not with inactive point mutants of these Ras-like GTPases. Moreover, using purified proteins, we demonstrate the direct GTP-dependent interaction of the Ras-like GTPases with RalGDS-RBD and full-length RalGDS in vitro. Furthermore, we show that RalGDS-RBD and the Ras-binding domain of Raf-1 compete for binding to the Ras-like GTPases. These data indicate that RalGDS is a putative effector molecule for R-ras, H-ras, K-ras, and Rap."xsd:string |
| http://purl.uniprot.org/citations/7809086 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.26.12609"xsd:string |
| http://purl.uniprot.org/citations/7809086 | http://purl.uniprot.org/core/author | "Bischoff J.R."xsd:string |
| http://purl.uniprot.org/citations/7809086 | http://purl.uniprot.org/core/author | "Spaargaren M."xsd:string |
| http://purl.uniprot.org/citations/7809086 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7809086 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/7809086 | http://purl.uniprot.org/core/pages | "12609-12613"xsd:string |
| http://purl.uniprot.org/citations/7809086 | http://purl.uniprot.org/core/title | "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap."xsd:string |
| http://purl.uniprot.org/citations/7809086 | http://purl.uniprot.org/core/volume | "91"xsd:string |
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