| http://purl.uniprot.org/citations/7809134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7809134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7809134 | http://www.w3.org/2000/01/rdf-schema#comment | "Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.26.12852"xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.26.12852"xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Koller B.H."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Koller B.H."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Goulet J.L."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Goulet J.L."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Snouwaert J.N."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Snouwaert J.N."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Coffman T.M."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Coffman T.M."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Latour A.M."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/author | "Latour A.M."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/pages | "12852-12856"xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/pages | "12852-12856"xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/title | "Altered inflammatory responses in leukotriene-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/title | "Altered inflammatory responses in leukotriene-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/7809134 | http://purl.uniprot.org/core/volume | "91"xsd:string |