| http://purl.uniprot.org/citations/7813017 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7813017 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7813017 | http://www.w3.org/2000/01/rdf-schema#comment | "Rat antizyme gene expression requires programmed, ribosomal frameshifting. A novel autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines. Antizyme binds to, and destabilizes, ornithine decarboxylase, a key enzyme in polyamine synthesis. Rapid degradation ensues, thus completing a regulatory circuit. In vitro experiments with a fusion construct using reticulocyte lysates demonstrate polyamine-dependent expression with a frameshift efficiency of 19% at the optimal concentration of spermidine. The frameshift is +1 and occurs at the codon just preceding the terminator of the initiating frame. Both the termination codon of the initiating frame and a pseudoknot downstream in the mRNA have a stimulatory effect. The shift site sequence, UCC-UGA-U, is not similar to other known frameshift sites. The mechanism does not seem to involve re-pairing of peptidyl-tRNA in the new frame but rather reading or occlusion of a fourth base."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90450-6"xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90450-6"xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Atkins J.F."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Atkins J.F."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Gesteland R.F."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Gesteland R.F."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Hayashi S."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Hayashi S."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Miyazaki Y."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Miyazaki Y."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Matsufuji S."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Matsufuji S."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Matsufuji T."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/author | "Matsufuji T."xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/pages | "51-60"xsd:string |
| http://purl.uniprot.org/citations/7813017 | http://purl.uniprot.org/core/pages | "51-60"xsd:string |