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| http://purl.uniprot.org/citations/7814377 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated an inositol hexakisphosphate binding protein from rat brain by affinity elution chromatography from Mono S cation exchange resin using 0.1 mM inositol hexakisphosphate (InsP6). The amino acid sequences of six tryptic peptides from the protein were identical to the sequences predicted from the cDNA encoding a previously isolated protein designated as AP-3 or AP180. This protein is localized in nerve endings and promotes assembly of clathrin into coated vesicles. The isolated protein-bound InsP6 with a dissociation constant of 1.2 microM and a stoichiometry of 0.9 mol of InsP6 bound/mol of AP-3. Recombinant AP-3 expressed in Escherichia coli also bound InsP6 with a similar affinity. InsP6 inhibited clathrin cage assembly mediated by AP-3, in an in vitro assay, but had little effect AP-3 binding to preformed cages. We speculate that InsP6 and perhaps highly phosphorylated inositol lipids may play a role in coated vesicle formation."xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.1.214"xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/author | "Majerus P.W."xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/author | "Ungewickell E."xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/author | "Norris F.A."xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/pages | "214-217"xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/title | "Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitro."xsd:string |
| http://purl.uniprot.org/citations/7814377 | http://purl.uniprot.org/core/volume | "270"xsd:string |
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