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http://purl.uniprot.org/citations/7826361http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7826361http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7826361http://www.w3.org/2000/01/rdf-schema#comment"Two analogs of omega-conotoxin MVIIA, a 25mer peptide neurotoxin, were synthesized by replacing Lys2 or Tyr13 with Ala. The activities of synthetic analogs were estimated from the inhibitory action on 125I-omega-conotoxin GVIA binding to chick brain synaptic plasma membranes. As in the case of omega-conotoxin GVIA, replacement of Tyr13 resulted in an enormous reduction in activity. In contrast, substitution of Ala for Lys2 gave only a small effect. These results indicate that Tyr13 is a critical amino acid of omega-conotoxin MVIIA and GVIA for blocking N-type calcium channel function."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1995.1063"xsd:string
http://purl.uniprot.org/citations/7826361http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1995.1063"xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Sato K."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Sato K."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Takahashi M."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Takahashi M."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Ohtake A."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Ohtake A."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Kim J.-I."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Kim J.-I."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Wakamiya A."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/author"Wakamiya A."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/pages"449-454"xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/pages"449-454"xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/title"Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/title"Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers."xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/volume"206"xsd:string
http://purl.uniprot.org/citations/7826361http://purl.uniprot.org/core/volume"206"xsd:string