| http://purl.uniprot.org/citations/7830863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7830863 | http://www.w3.org/2000/01/rdf-schema#comment | "The clinical course of murine hereditary nephrotic syndrome (ICGN strain) was determined by examining 201 animals under different conditions. In the early stage, significant hypoproteinemia and hypoalbuminemia developed (p < 0.001) in parallel with a progressive rise in urinary protein concentration (p < 0.001). In the middle stage, the concentrations of total cholesterol, triglyceride, and beta-lipoprotein markedly increased (p < 0.01, p < 0.001, and p < 0.001, respectively), suggesting that type IIb hyperlipoproteinemia developed as in human nephrotic patients. Systemic edema appeared in 8 of 24 animals. In the terminal stage, both BUN and creatinine values greatly increased (p < 0.001), indicating rapid deterioration of renal function. The present study suggests that ICGN mice could be a useful model to study the pathophysiology of human nephrotic syndrome and its progression to renal failure."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.org/dc/terms/identifier | "doi:10.1159/000188264"xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/author | "Kawaguchi H."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/author | "Suzuki O."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/author | "Yamamoto Y."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/author | "Yamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/author | "Asano T."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/author | "Noguchi Y."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/author | "Ogura A."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/name | "Nephron"xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/pages | "239-244"xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/title | "Hereditary nephrotic syndrome with progression to renal failure in a mouse model (ICGN strain): clinical study."xsd:string |
| http://purl.uniprot.org/citations/7830863 | http://purl.uniprot.org/core/volume | "68"xsd:string |
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