| http://purl.uniprot.org/citations/7831296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7831296 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid (RA) has been proposed to be a direct regulator of HOX gene complexes. However, the molecular mechanism of the RA signaling pathway during normal development is unclear. We have identified an RA-responsive element in the promoter of HOXB1 gene composed of two functionally separable sites: (i) a DR-2 sequence, which is the direct target of the RA receptor retinoid X receptor heterodimer; and (ii) a motif for an RA-inducible and tissue-specific coactivator termed retinoid-inducible protein. Through neither enhancer alone is functional, this combined element strongly activates the HOXB1 promoter in a cell-specific and retinoid-dependent manner. Finally, this activation is potentiated by a proximal autoregulatory site for HOXB1 gene itself. These data define a tripartite cascade leading to the establishment of HOXB1 gene activation."xsd:string |
| http://purl.uniprot.org/citations/7831296 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.2.387"xsd:string |
| http://purl.uniprot.org/citations/7831296 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/7831296 | http://purl.uniprot.org/core/author | "Ogura T."xsd:string |
| http://purl.uniprot.org/citations/7831296 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7831296 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/7831296 | http://purl.uniprot.org/core/pages | "387-391"xsd:string |
| http://purl.uniprot.org/citations/7831296 | http://purl.uniprot.org/core/title | "A retinoic acid-triggered cascade of HOXB1 gene activation."xsd:string |
| http://purl.uniprot.org/citations/7831296 | http://purl.uniprot.org/core/volume | "92"xsd:string |
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