| http://purl.uniprot.org/citations/7838537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7838537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7838537 | http://www.w3.org/2000/01/rdf-schema#comment | "To elucidate the role that protein tyrosine phosphatase (PTPs) may play in liver regeneration, PTPs expressed in the mouse liver after partial hepatectomy (PH) were investigated by a PCR-based cloning method. Sequencing of 115 cDNA clones identified 10 different sequences including MPTP (T cell PTP), PTP-1B, PTP-P19, mR-PTP mu, R-PTP alpha, PTP NE-3 (PTP-P1), R-PTP-kappa and the murine homologue of human LAR. The remaining two sequences, PTP-RL9 and PTP-RL10, encoded novel PTPs. PTP-RL10 cDNA contained an open reading frame of 1176 amino acids with no apparent membrane-spanning region. The amino-terminal region had sequence homology to those of human erythrocyte protein 4.1 and ezrin, cytoskeletal proteins. In the regenerating liver, the levels of five PTP gene mRNAs (MPTP, PTP-P19, R-PTP alpha, LAR homologue, and PTP-RL9) increased within 6 h, decreased to the normal level by 24 h, and increased again at 48 to 72 h after PH. The levels of PTP-1B and R-PTP-kappa mRNAs peaked within 6 h, decreased gradually, and returned to the normal level by 168 h after PH. In contrast, the levels of two PTP mRNAs (mR-PTP mu and PTP-RL10) peaked at 48 to 72 h, and returned to the normal level by 168 h after PH. No expression of PTP NE-3 was detected in the liver by Northern blotting. The differential expression of multiple PTPs during the pre-replicative and post-replicative stages of liver regeneration suggests that PTPs are involved in the regulation of growth and differentiation of liver cells."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Nakayama H."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Nakayama H."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Furutani M."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Furutani M."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Imamura M."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Imamura M."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Kaneko Y."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Kaneko Y."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Fujita J."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Fujita J."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Arii S."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Arii S."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Higashitsuji H."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Higashitsuji H."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Takenawa J."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/author | "Takenawa J."xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/pages | "407-414"xsd:string |
| http://purl.uniprot.org/citations/7838537 | http://purl.uniprot.org/core/pages | "407-414"xsd:string |