| http://purl.uniprot.org/citations/7844144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7844144 | http://www.w3.org/2000/01/rdf-schema#comment | "The distribution and dynamics of both the ER and Golgi complex in animal cells are known to be dependent on microtubules; in many cell types the ER extends toward the plus ends of microtubules at the cell periphery and the Golgi clusters at the minus ends of microtubules near the centrosome. In this study we provide evidence that the microtubule motor, kinesin, is present on membranes cycling between the ER and Golgi and powers peripherally directed movements of membrane within this system. Immunolocalization of kinesin at both the light and electron microscopy levels in NRK cells using the H1 monoclonal antibody to kinesin heavy chain, revealed kinesin to be associated with all membranes of the ER/Golgi system. At steady-state at 37 degrees C, however, kinesin was most concentrated on peripherally distributed, pre-Golgi structures containing beta COP and vesicular stomatitis virus glycoprotein newly released from the ER. Upon temperature reduction or nocodazole treatment, kinesin's distribution shifted onto the Golgi, while with brefeldin A (BFA)-treatment, kinesin could be found in both Golgi-derived tubules and in the ER. This suggested that kinesin associates with membranes that constitutively cycle between the ER and Golgi. Kinesin's role on these membranes was examined by microinjecting kinesin antibody. Golgi-to-ER but not ER-to-Golgi membrane transport was found to be inhibited by the microinjected anti-kinesin, suggesting kinesin powers the microtubule plus end-directed recycling of membrane to the ER, and remains inactive on pre-Golgi intermediates that move toward the Golgi complex."xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.128.3.293"xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/author | "Cole N.B."xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/author | "Conrad P.A."xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/author | "Lippincott-Schwartz J."xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/author | "Marotta A."xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/author | "Bloom G.S."xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/pages | "293-306"xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/title | "Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic."xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/7844144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7844144 |
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