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http://purl.uniprot.org/citations/7852402http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7852402http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7852402http://www.w3.org/2000/01/rdf-schema#comment"A cDNA encoding the major core protein, p50, of cytoplasmic messenger ribonucleoprotein particles (mRNPs) of somatic cells was cloned from a rabbit reticulocyte cDNA library. From the derived 324-amino acid sequence, p50 is identified as a member of the Y-box binding transcription factor family. The protein was earlier described as a repressor of globin mRNA translation. These findings suggest that p50 may affect protein biosynthesis at two levels: mRNA transcription in the nucleus and mRNA translation in the cytoplasm. Together with recently published results showing that masked mRNA in germ cells also is associated with proteins of the Y-box binding protein family, the present finding indicates that these proteins are universal core proteins responsible for the formation of cytoplasmic mRNPs in eukaryotes. Highly purified p50 forms large 18 S homomultimeric complexes with a molecular mass of about 800 kilodaltons and melts RNA secondary structure. This suggests that p50 may affect translation by changing the overall structure of the mRNA."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.org/dc/terms/identifier"doi:10.1074/jbc.270.7.3186"xsd:string
http://purl.uniprot.org/citations/7852402http://purl.org/dc/terms/identifier"doi:10.1074/jbc.270.7.3186"xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Wei C.L."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Wei C.L."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Hershey J.W."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Hershey J.W."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Evdokimova V.M."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Evdokimova V.M."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Lazarev O.A."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Lazarev O.A."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Ovchinnikov L.P."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Ovchinnikov L.P."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Simonenko P.N."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Simonenko P.N."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Sitikov A.S."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Sitikov A.S."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Ustinov V.A."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Ustinov V.A."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Vasilenko K.S."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/author"Vasilenko K.S."xsd:string
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7852402http://purl.uniprot.org/core/date"1995"xsd:gYear