| http://purl.uniprot.org/citations/7861179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7861179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7861179 | http://www.w3.org/2000/01/rdf-schema#comment | "A cDNA clone encoding a human gamma-aminobutyric acid (GABA) transporter has been isolated from a brain cDNA library, and its functional properties have been examined in mammalian cells. The nucleotide sequence predicts a transporter with 614 amino acids and 12 putative transmembrane domains. The highest degree of amino acid identity is with a betaine/GABA transporter originally cloned from the dog termed BGT-1 (91%) and a related transporter from mouse brain (87%). These identities are similar to those for species homologues of other neurotransmitter transporters and suggest that the new clone represents the human homologue of BGT-1. The transporter displays high affinity for GABA (IC50 of 30 microM) and is also sensitive to phloretin, L-2,4-diaminobutyric acid, and hypotaurine (IC50 values of approximately 150-400 microM). The osmolyte betaine is approximately 25-fold weaker than GABA, displaying an IC50 of approximately 1 mM. The relative potencies of these inhibitors at human BGT-1 differ from those of mouse and dog BGT-1. Northern blot analysis reveals that BGT-1 mRNA is widely distributed throughout the human brain. The cloning of the human homologue of BGT-1 will further our understanding of the roles of GABA and betaine in neural function."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.1995.64030977.x"xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.1995.64030977.x"xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Branchek T.A."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Branchek T.A."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Weinshank R.L."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Weinshank R.L."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Smith K.E."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Smith K.E."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Gustafson E.L."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Gustafson E.L."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Borden L.A."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/author | "Borden L.A."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/pages | "977-984"xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/pages | "977-984"xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/title | "Cloning and expression of a betaine/GABA transporter from human brain."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/title | "Cloning and expression of a betaine/GABA transporter from human brain."xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/7861179 | http://purl.uniprot.org/core/volume | "64"xsd:string |