| http://purl.uniprot.org/citations/7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7862124 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-kappa B is an important activator of immune and inflammatory response genes. NF-kappa B is sequestered in the cytoplasm of nonstimulated cells through interaction with the I kappa B inhibitors. These inactive complexes are dissociated in response to a variety of extracellular signals, thereby allowing free NF-kappa B dimers to translocate to the nucleus and active transcription of specific target genes. The current dogma is that phosphorylation of the I kappa Bs is responsible for dissociation of the inactive complexes, an event that is rendered irreversible by rapid I kappa B degradation. Here, we show that inducers of NF-kappa B activity stimulate the hyperphosphorylation of one of the I kappa Bs, I kappa B alpha. However, contrary to the present dogma the hyperphosphorylated form of I kappa B alpha remains associated with NF-kappa B components such as RelA (p65). Thus, phosphorylation of I kappa B alpha is not sufficient to cause dissociation of the inactive NF-kappa B:I kappa B alpha complex. However, that complex is disrupted through the selective degradation of phosphorylated I kappa B alpha in response to extracellular signals. Using a variety of protease inhibitors, some of which have specificity towards the multicatalytic proteinase complex, we demonstrate that degradation of I kappa B alpha is required for NF-kappa B activation. The results of these experiments are more consistent with a new model according to which phosphorylation of I kappa B alpha associated with NF-kappa B marks it for proteolytic degradation. I kappa B alpha is degraded while bound to NF-kappa B. The selective degradation of I kappa B alpha releases active NF-kappa B dimers which can translocate to the nucleus to activate specific target genes."xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.15.3.1302"xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/author | "DiDonato J.A."xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/author | "Mercurio F."xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/pages | "1302-1311"xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/title | "Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B."xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/7862124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7862124 |
| http://purl.uniprot.org/citations/7862124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7862124 |
| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_Q15653-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_A5LHX3-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_P19838-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_Q13200-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_Q14997-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_O00221-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_O00231-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_O00232-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |
| http://purl.uniprot.org/uniprot/#_O00233-mappedCitation-7862124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7862124 |