http://purl.uniprot.org/citations/7862126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7862126 | http://www.w3.org/2000/01/rdf-schema#comment | "We have used the yeast two-hybrid system to isolate proteins that interact with the carboxy-terminal SH3-SH2-SH3 region of Vav. One of the clones encoded heterogeneous nuclear ribonucleoprotein K (hnRNP K), a poly(rC)-specific RNA-binding protein. The interaction between Vav and hnRNP K involves the binding of the most carboxy-terminal SH3 domain of Vav to two proline-rich sequences present in the central region of hnRNP K. Overexpression of Vav in mouse fibroblasts leads to the formation of a stable complex with the endogenous hnRNP K and to the preferential redistribution of this protein to the cytoplasmic fraction. More importantly, Vav and hnRNP K proteins also interact in hematopoietic cells. In addition, Vav associates in vitro with a second 45-kDa poly(rC)-specific RNA-binding protein via its SH3-SH2-SH3 region. These results suggest that Vav plays a role in the regulation of the late steps of RNA biogenesis by modulating the function of poly(rC)-specific ribonucleoproteins."xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.15.3.1324"xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/author | "Michael W.M."xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/author | "Barbacid M."xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/author | "Dreyfuss G."xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/author | "Bustelo X.R."xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/author | "Suen K.L."xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/pages | "1324-1332"xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/title | "Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins."xsd:string |
http://purl.uniprot.org/citations/7862126 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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