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| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/7862164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7862164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7862164 | http://www.w3.org/2000/01/rdf-schema#comment | "We have characterized a newly identified gene from Dictyostelium discoideum, DdTBP alpha, that encodes a member of the family of eukaryotic proteins. These proteins contain a conserved ATPase domain, include subunits of the 26S protease subunit, and are homologous to the mammalian human immunodeficiency virus Tat-binding protein TBP1. While information indicates that some family members are involved in the regulation of transcription in mammalian and yeast cells during growth, these proteins are also involved in other cellular functions, and nothing is known about their possible function in multicellular development. The Dictyostelium DdTBP alpha gene is developmentally regulated, with its expression at the highest levels occurring during growth and early development. The gene is present in two copies in the genome. Disruption of one copy by homologous recombination leads to aberrant morphogenesis, which lasts from the formation of the first finger until the onset of culmination. The gene appears to be essential for growth since we were unable to obtain a complete null phenotype and since expression of an inducible antisense construct in the partial null background resulted in cell death. Expression of the antisense construct during development accentuated the partial null phenotype and also resulted in very abnormal fruiting bodies. Overexpression of DdTBP alpha from its own promoter leads to very large multinucleated vegetative cells when the cells are grown in suspension culture. When the cells are plated onto petri dishes in growth medium, they rapidly split into multiple cells containing one to two nuclei, in a manner similar to that of wild-type cells. Overexpressing cells are significantly delayed in forming a multicellular aggregate, but development proceeds normally once the first finger stage is reached. The results indicate that DdTBP alpha plays an important role in regulating both growth and morphogenesis in D. discoideum."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.15.3.1725"xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.15.3.1725"xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/author | "Firtel R.A."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/author | "Firtel R.A."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/author | "Cao J.-G."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/author | "Cao J.-G."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/pages | "1725-1736"xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/pages | "1725-1736"xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/title | "Growth and developmental functions of a human immunodeficiency virus Tat-binding protein/26S protease subunit homolog from Dictyostelium discoideum."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/title | "Growth and developmental functions of a human immunodeficiency virus Tat-binding protein/26S protease subunit homolog from Dictyostelium discoideum."xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/7862164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7862164 |
| http://purl.uniprot.org/citations/7862164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7862164 |
| http://purl.uniprot.org/citations/7862164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7862164 |
| http://purl.uniprot.org/citations/7862164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7862164 |
| http://purl.uniprot.org/uniprot/Q55BV5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7862164 |
| http://purl.uniprot.org/uniprot/Q55BV5#SIP1D50482EA76BFDC0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7862164 |