| http://purl.uniprot.org/citations/7891887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7891887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7891887 | http://www.w3.org/2000/01/rdf-schema#comment | "The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.org/dc/terms/identifier | "doi:10.1016/0304-3940(94)90204-6"xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.org/dc/terms/identifier | "doi:10.1016/0304-3940(94)90204-6"xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Roses A.D."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Roses A.D."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Pericak-Vance M.A."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Pericak-Vance M.A."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Garner C.C."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Garner C.C."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Saunders A.M."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Saunders A.M."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Weisgraber K.H."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Weisgraber K.H."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Goedert M."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Goedert M."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Huang D.Y."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Huang D.Y."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Jakes R."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Jakes R."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Schmechel D.E."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Schmechel D.E."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Strittmatter W.J."xsd:string |
| http://purl.uniprot.org/citations/7891887 | http://purl.uniprot.org/core/author | "Strittmatter W.J."xsd:string |