| http://purl.uniprot.org/citations/7896880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7896880 | http://www.w3.org/2000/01/rdf-schema#comment | "A family of genes related to the bcl-2 protooncogene has recently emerged. One member of this family, mcl-1, was cloned from a human myeloblastic leukemia cell line (ML-1) undergoing differentiation. The intracellular localization of mcl-1, as well as the kinetics of its expression during differentiation, have now been studied. These studies show that the intracellular distribution of mcl-1 overlaps with, but is not identical to, that of bcl-2: mcl-1 is similar to bcl-2 in that the mcl-1 protein has a prominent mitochondrial localization, and in that it associates with membranes through its carboxyl hydrophobic tail. mcl-1 differs from bcl-2, however, in its relative distribution among other (nonmitochondrial/heavy membrane) compartments, mcl-1 also being abundant in the light membrane fraction of immature ML-1 cells while bcl-2 is abundant in the nuclear fraction. Similarly, in differentiating ML-1 cells, the timing of expression of mcl-1 overlaps with, but is not identical to, that of bcl-2: the mcl-1 protein increases rapidly as cells initiate differentiation, and mcl-1 is a labile protein. In contrast, bcl-2 decreases gradually as cells complete differentiation. Overall, the mcl-1 and bcl-2 proteins have some properties in common and others tht are distinct. A burst of expression of mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells differentiating along the monocyte/macrophage pathway."xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.128.6.1173"xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/author | "Yang T."xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/author | "Craig R.W."xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/author | "Kozopas K.M."xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/pages | "1173-1184"xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/title | "The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2."xsd:string |
| http://purl.uniprot.org/citations/7896880 | http://purl.uniprot.org/core/volume | "128"xsd:string |
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