| http://purl.uniprot.org/citations/7899075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7899075 | http://www.w3.org/2000/01/rdf-schema#comment | "The S. cerevisiae Uga43(Dal80) protein down-regulates the expression of multiple nitrogen pathway genes. It contains a zinc-finger motif similar to the DNA-binding domain of the vertebrate GATA family of transcription factors; this domain is known to direct binding to 5'-GATA-3' core sequences. The inducible UGA4 gene, which encodes the specific gamma-aminobutyrate permease, undergoes strong repression by Uga43p. This study shows that the 5' region of UGA4 contains a UAS element made of four directly repeated 5'-CGAT(A/T) AG-3' sequences. This element, called UASGATA, can potentially confer to the UGA4 gene high-level expression in the absence of inducer, but this potential activity is inhibited by two distinct repression systems. One system is Uga43p-dependent; it operates in cells grown on a poor nitrogen source. The other is the nitrogen repression system, which relies on Ure2p and glutamine and operates when a good nitrogen source is present. Nitrogen repression also blocks the synthesis of Uga43p, making the two repression systems mutually exclusive. Previous studies have shown that expression supported by 5'-GATA-3'-containing UAS elements requires Gln3p, another global nitrogen regulatory factor containing a GATA zinc-finger domain. Although Gln3p contributes to UASGATA activity, evidence suggests that a second factor can potentially direct expression through UASGATA. Expression conferred by this putative factor is subject to both Uga43p- and Ure2p-mediated repression. The role of UASGATA in the expression of the UGA4 gene is discussed in relation to its sensitivity to the two distinct repression systems."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/23.4.558"xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/author | "Andre B."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/author | "Hein C."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/author | "Vissers S."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/author | "Talibi D."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/author | "Coornaert D."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/author | "Soussi Boudekou S."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/pages | "558-564"xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/title | "Two mutually exclusive regulatory systems inhibit UASGATA, a cluster of 5'-GAT(A/T)A-3' upstream from the UGA4 gene of Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/7899075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7899075 |
| http://purl.uniprot.org/citations/7899075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7899075 |
| http://purl.uniprot.org/uniprot/P26343#attribution-AA88BCBBC98649B731DE9E6689E15A43 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7899075 |
| http://purl.uniprot.org/uniprot/#_P26343-mappedCitation-7899075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7899075 |
| http://purl.uniprot.org/uniprot/P26343 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7899075 |