RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/7902583http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7902583http://www.w3.org/2000/01/rdf-schema#comment"SWI5 encodes a zinc-finger protein required for expression of the yeast HO gene. Using Swi5 protein that was purified from a bacterial expression system, we previously isolated a yeast factor that stimulates binding of Swi5 to the HO promoter. N-terminal amino acid sequence analysis identified the Swi5 stimulatory factor as the product of the GRF10 gene, which encodes a yeast homeodomain protein. GRF10, also known as PHO2 and BAS2, is a transcriptional activator of the PHO5 acid phosphatase gene and the HIS4 histidine biosynthesis gene. Grf10 protein purified from a bacterial expression system binds DNA cooperatively with Swi5 in vitro. Analysis of disassociation rates indicates that the Grf10-Swi5-DNA complex has a longer half-life than protein-DNA complexes that contain only Swi5 or Grf10. Finally, we show that HO expression is reduced in yeast strains containing grf10 null mutations and that full expression of a heterologous promoter containing a SWI5-dependent HO upstream activation sequence element requires GRF10."xsd:string
http://purl.uniprot.org/citations/7902583http://purl.org/dc/terms/identifier"doi:10.1073/pnas.90.23.11237"xsd:string
http://purl.uniprot.org/citations/7902583http://purl.uniprot.org/core/author"Brazas R.M."xsd:string
http://purl.uniprot.org/citations/7902583http://purl.uniprot.org/core/author"Stillman D.J."xsd:string
http://purl.uniprot.org/citations/7902583http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/7902583http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/7902583http://purl.uniprot.org/core/pages"11237-11241"xsd:string
http://purl.uniprot.org/citations/7902583http://purl.uniprot.org/core/title"The Swi5 zinc-finger and Grf10 homeodomain proteins bind DNA cooperatively at the yeast HO promoter."xsd:string
http://purl.uniprot.org/citations/7902583http://purl.uniprot.org/core/volume"90"xsd:string
http://purl.uniprot.org/citations/7902583http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7902583
http://purl.uniprot.org/citations/7902583http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/7902583
http://purl.uniprot.org/uniprot/P07269#attribution-D09A07C7514F8ACCAA76985726394DEChttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/7902583
http://purl.uniprot.org/uniprot/P07269#attribution-E9300BCEA41417D4EAD81F147530FA45http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/7902583
http://purl.uniprot.org/uniprot/#_P08153-mappedCitation-7902583http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7902583
http://purl.uniprot.org/uniprot/#_P07269-mappedCitation-7902583http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7902583
http://purl.uniprot.org/uniprot/P07269http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/7902583
http://purl.uniprot.org/uniprot/P08153http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/7902583