http://purl.uniprot.org/citations/7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7906860 | http://www.w3.org/2000/01/rdf-schema#comment | "A cell-free system was used to examine heat shock protein 90 (hsp90)-progesterone receptor (PR) binding at near physiological conditions. Four major findings are presented: 1) hsp90 is required to maintain ligand binding by PR at elevated temperatures; 2) hsp70 and heat shock-related protein p60 are components of an intermediate assembly complex that precedes formation of a mature hsp90-PR complex; 3) hsp90-PR complexes are in a steady state assembly/disassembly cycle (t1/2, 5 min); and 4) hsp90 dissociation is not accelerated after progesterone binding; instead, progesterone prevents PR from forming hsp70-mediated assembly complexes. A model incorporating these findings is presented in which unliganded PR is maintained in a disactivation loop of assembly/disassembly with hsp90; hormone binding releases PR from this loop to proceed along an activation pathway."xsd:string |
http://purl.uniprot.org/citations/7906860 | http://purl.org/dc/terms/identifier | "doi:10.1210/mend.7.11.7906860"xsd:string |
http://purl.uniprot.org/citations/7906860 | http://purl.uniprot.org/core/author | "Smith D.F."xsd:string |
http://purl.uniprot.org/citations/7906860 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
http://purl.uniprot.org/citations/7906860 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
http://purl.uniprot.org/citations/7906860 | http://purl.uniprot.org/core/pages | "1418-1429"xsd:string |
http://purl.uniprot.org/citations/7906860 | http://purl.uniprot.org/core/title | "Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes."xsd:string |
http://purl.uniprot.org/citations/7906860 | http://purl.uniprot.org/core/volume | "7"xsd:string |
http://purl.uniprot.org/citations/7906860 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7906860 |
http://purl.uniprot.org/citations/7906860 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7906860 |
http://purl.uniprot.org/uniprot/#_P03372-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_P08238-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_Q13451-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_P07900-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_P53041-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_Q02790-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_Q08752-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_Q15185-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/#_Q92731-mappedCitation-7906860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/Q92731 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/Q15185 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/P08238 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/P07900 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7906860 |
http://purl.uniprot.org/uniprot/P03372 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7906860 |