| http://purl.uniprot.org/citations/7911422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7911422 | http://www.w3.org/2000/01/rdf-schema#comment | "The present investigation explored age-related alterations in T cell populations mediating allospecific responses in vivo. Healthy aged and young H-2b and H-2bxH-2k mice were engrafted with major histocompatibility complex (MHC) class II-disparate bm12 skin, rejection of which requires CD8+ T cells, and MHC class I-disparate bm1 skin, rejection of which requires CD8+ T cells. Aged mice of both genders exhibited prolonged survival of bm12 skin grafts relative to their young counterparts but rejected bm1 skin grafts at a rate equivalent to that of young mice. Consistent with prolonged survival of bm12 skin grafts, markedly diminished levels of Iabm12 CTL activity were elicited from T cells of aged mice in vitro. However, no such decline was observed in the level of Kbm1 CTL from T cells of aged mice. The alterations in Iabm12 allospecific responses were not attributable to quantitative changes in CD4+ T cells of aged mice, and addition of soluble T cell helper factors to response cultures of aged mice did not augment Iabm12 cytotoxic T lymphocytes activity. These data demonstrate that aging fundamentally affects CD4+ T cell-mediated allospecific responses particularly in vivo, and that deficient generation of soluble T cell helper factors alone cannot explain this deficit."xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.1830240611"xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/author | "Bloom E.T."xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/author | "Horvath J.A."xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/author | "Maniero T.G."xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/author | "Rosenberg A.S."xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/author | "Sechler J.M."xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/pages | "1312-1316"xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/title | "Assessment of alloreactive T cell subpopulations of aged mice in vivo. CD4+ but not CD8+ T cell-mediated rejection response declines with advanced age."xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/7911422 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7911422 |
| http://purl.uniprot.org/citations/7911422 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7911422 |
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| http://purl.uniprot.org/uniprot/#_P06343-mappedCitation-7911422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7911422 |
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| http://purl.uniprot.org/uniprot/#_P06346-mappedCitation-7911422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7911422 |
| http://purl.uniprot.org/uniprot/#_Q31135-mappedCitation-7911422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7911422 |
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| http://purl.uniprot.org/uniprot/#_Q31187-mappedCitation-7911422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7911422 |