| http://purl.uniprot.org/citations/7912658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7912658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7912658 | http://www.w3.org/2000/01/rdf-schema#comment | "P-glycoproteins (P-gps) encoded by the mouse mdr2 and mdr3 genes were expressed in secretory vesicles (SVs) from the yeast mutant sec6-4, and their capacity to function as a lipid translocase/flippase was tested. An assay that uses a fluorescent phosphatidylcholine (PC) analog was developed to quantitate asymmetric lipid distribution in the outer and inner leaflets of the lipid bilayer of these vesicles. Mdr2 expression in SVs caused a time- and temperature-dependent enhancement of PC translocation to the inner leaflet of the membrane. The Mdr2-mediated effect was specific since expression of Mdr3 in these vesicles was without effect on the membrane distribution of PC. Increased Mdr2-mediated PC translocation was strictly ATP and Mg2+ dependent, was abrogated by the ATPase inhibitor vanadate and the P-gp modulator verapamil, but was insensitive to the presence of excess of the multidrug resistance drugs colchicine and vinblastine."xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90446-4"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90446-4"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/author | "Ruetz S."xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/author | "Ruetz S."xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/pages | "1071-1081"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/pages | "1071-1081"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/title | "Phosphatidylcholine translocase: a physiological role for the mdr2 gene."xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/title | "Phosphatidylcholine translocase: a physiological role for the mdr2 gene."xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/7912658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7912658 |
| http://purl.uniprot.org/citations/7912658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7912658 |
| http://purl.uniprot.org/citations/7912658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7912658 |
| http://purl.uniprot.org/citations/7912658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7912658 |
| http://purl.uniprot.org/uniprot/P21440 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7912658 |
| http://purl.uniprot.org/uniprot/P21439#attribution-CB66E61FC77BEEC30F0BAE9D728548B7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7912658 |