| http://purl.uniprot.org/citations/7931420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7931420 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined insulin-like growth factor I (IGF-I)-dependent phosphorylation and protein tyrosine kinase (PTK) activity in cerebellar cortex of normal humans, patients with olivopontocerebellar atrophy (OPCA) ("C" kindred) and in lurcher mutant mouse, a suggested animal model for OPCA. PTK activity and IGF-I-dependent protein tyrosine phosphorylation was significantly reduced in cerebellar cortex of human OPCA patients as compared to the normal controls. Immunoblot analysis also demonstrated a decrease in cerebellar 80 kDa phosphotyrosine protein in these patients. By autoradiography, IGF-I receptors were localized in the molecular layer of 30-day-old control and lurcher mutant mice cerebella. However, the lurcher mutant mice showed a decrease in [125I]-IGF-I binding in the molecular layer as compared to the littermate controls. The IGF-I receptor autophosphorylation was also markedly reduced in 15-day- and 22-day-old lurcher cerebella. These results suggest that the process of cerebellar degeneration in human OPCA and lurcher mutant mouse may be associated with altered IGF-I receptor binding and protein tyrosine phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.org/dc/terms/identifier | "doi:10.1016/0022-510x(94)90008-6"xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/author | "Joshi P."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/author | "Subramony S.H."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/author | "Fratkin J.D."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/author | "Currier R.D."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/author | "Desaiah D."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/author | "Vig P.J."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/name | "J Neurol Sci"xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/pages | "38-44"xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/title | "Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse."xsd:string |
| http://purl.uniprot.org/citations/7931420 | http://purl.uniprot.org/core/volume | "124"xsd:string |
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