| http://purl.uniprot.org/citations/7931697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7931697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7931697 | http://www.w3.org/2000/01/rdf-schema#comment | "Selenoprotein P is a glycoprotein that has been purified from rat and human plasma. In selenium-replete rats it contains 65% of the plasma selenium and its concentration is 25-30 mg protein/L. In selenium-deficient rats its concentration is < 3 mg protein/L. The plasma half life of 75Se in selenoprotein P is 3 to 4 h, indicating a rapid turnover. Purified rat selenoprotein P contains 7.5 +/-1 selenium atoms per molecule as selenocysteine. The sequence of the cloned cDNA predicts 10 selenocysteine residues, which suggests that the protein in plasma is a modification of the predicted one. Deduced amino acid sequence identity between rats and humans is 72%. The 3' untranslated region of selenoprotein P cDNA contains two predicted stem loops of the type essential for selenocysteine incorporation. Northern analysis indicates that selenoprotein P is expressed by many tissues. Hepatic selenoprotein P mRNA level, but not its transcription, decreases during selenium deficiency. The decrease is less than the decrease of glutathione peroxidase mRNA, however. Selenoprotein P is postulated to serve as an extracellular oxidant defense because its presence correlates with selenium protection of selenium-deficient rats against diquat-induced lipid peroxidation and liver necrosis. More research will be required to test this hypothesis and to establish the biochemical function of selenoprotein P."xsd:string |
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| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/author | "Hill K.E."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/author | "Hill K.E."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/author | "Burk R.F."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/author | "Burk R.F."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/name | "J. Nutr."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/name | "J. Nutr."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/pages | "1891-1897"xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/pages | "1891-1897"xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/title | "Selenoprotein P. A selenium-rich extracellular glycoprotein."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/title | "Selenoprotein P. A selenium-rich extracellular glycoprotein."xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/7931697 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7931697 |
| http://purl.uniprot.org/citations/7931697 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7931697 |
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| http://purl.uniprot.org/uniprot/P25236 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7931697 |