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http://purl.uniprot.org/citations/7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7935483http://www.w3.org/2000/01/rdf-schema#comment"The clonal expansion of antigen-stimulated T-lymphocytes during an immune response is mediated by several lymphokines. Strong evidence now exists that the neuroendocrine hormone PRL is necessary, but not sufficient, for T-cell proliferation. Little is known, however, of the signal transduction mechanisms of the PRL receptor (PRLR) within T-cells. We demonstrate here that PRL stimulation of the T-cell line Nb2 induced the concentration- and time-dependent activation of the protein tyrosine kinase p59fyn, but not of four other src family protein tyrosine kinases. Activation of fyn was also observed in Concanavalin-A-primed peripheral blood lymphocytes stimulated with PRL and in Nb2 cells incubated with anti-PRLR antibodies. The activation of fyn by PRL stimulation correlated with Nb2 cell proliferation. Immunoblot analysis of anti-fyn and anti-PRLR immune complexes revealed an association between each PRLR isoform and p59fyn. These studies demonstrate for the first time an association between the PRLR and a src family protein tyrosine kinase affiliated with signal transduction."xsd:string
http://purl.uniprot.org/citations/7935483http://purl.org/dc/terms/identifier"doi:10.1210/mend.8.6.7935483"xsd:string
http://purl.uniprot.org/citations/7935483http://purl.uniprot.org/core/author"Clevenger C.V."xsd:string
http://purl.uniprot.org/citations/7935483http://purl.uniprot.org/core/author"Medaglia M.V."xsd:string
http://purl.uniprot.org/citations/7935483http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/7935483http://purl.uniprot.org/core/name"Mol Endocrinol"xsd:string
http://purl.uniprot.org/citations/7935483http://purl.uniprot.org/core/pages"674-681"xsd:string
http://purl.uniprot.org/citations/7935483http://purl.uniprot.org/core/title"The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes."xsd:string
http://purl.uniprot.org/citations/7935483http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/7935483http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7935483
http://purl.uniprot.org/citations/7935483http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/7935483
http://purl.uniprot.org/uniprot/Q62844#attribution-C603F56D2F630BEBDBDB7EC362243A1Chttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/P05710#attribution-C603F56D2F630BEBDBDB7EC362243A1Chttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A0G2K600-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A0G2K813-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A0G2K2E3-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A0G2K488-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A096MKC1-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A096MKC5-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A8I5ZRL2-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A8I5ZSH8-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A8I5ZWH3-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_A0A8I6A612-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483
http://purl.uniprot.org/uniprot/#_Q58DZ7-mappedCitation-7935483http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7935483