http://purl.uniprot.org/citations/7954792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7954792 | http://www.w3.org/2000/01/rdf-schema#comment | "When yeast cells reach a critical size, they initiate bud formation, spindle pole body duplication, and DNA replication almost simultaneously. All three events depend on activation of Cdc28 protein kinase by the G1 cyclins Cln1, -2, and -3. We show that DNA replication also requires activation of Cdc28 by B-type (Clb) cyclins. A sextuple clb1-6 mutant arrests as multibudded G1 cells that resemble cells lacking the Cdc34 ubiquitin-conjugating enzyme. cdc34 mutants cannot enter S phase because they fail to destroy p40SIC1, which is a potent inhibitor of Clb but not Cln forms of the Cdc28 kinase. In wild-type cells, p40SIC1 protein appears at the end of mitosis and disappears shortly before S phase. Proteolysis of a cyclin-specific inhibitor of Cdc28 is therefore an essential aspect of the G1 to S phase transition."xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90193-7"xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/author | "Nasmyth K."xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/author | "Schwob E."xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/author | "Mendenhall M.D."xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/author | "Bohm T."xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/pages | "233-244"xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/title | "The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae."xsd:string |
http://purl.uniprot.org/citations/7954792 | http://purl.uniprot.org/core/volume | "79"xsd:string |
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http://purl.uniprot.org/citations/7954792 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7954792 |
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http://purl.uniprot.org/uniprot/P38634#attribution-FDACA336E385ADA2B8736059C4987DEF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7954792 |
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