| http://purl.uniprot.org/citations/7957045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7957045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7957045 | http://www.w3.org/2000/01/rdf-schema#comment | "An adult mouse liver cDNA library was screened with oligonucleotides corresponding to the conserved WSXWS motif of the haemopoietin receptor family. Using this method, cDNA clones encoding a novel receptor were isolated. The new receptor, named NR1, was most similar in sequence and predicted structure to the alpha-chain of the IL-6 receptor and mRNA was expressed in the 3T3-L1 pre-adipocytic cell line and in a range of primary tissues. Expression of NR1 in the factor-dependent haemopoietic cell line Ba/F3 resulted in the generation of low affinity receptors for IL-11 (Kd approximately 10 nM). The capacity to bind IL-11 with high affinity (Kd = 300-800 pM) appeared to require coexpression of both NR1 and gp130, the common subunit of the IL-6, leukaemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) receptors. The expression of both NR1 and gp130 was also necessary for Ba/F3 cells to proliferate and M1 cells to undergo macrophage differentiation in response to IL-11."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06802.x"xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06802.x"xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Hilton A.A."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Hilton A.A."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Hilton D.J."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Hilton D.J."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Gough N.M."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Gough N.M."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Metcalf D."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Metcalf D."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Nicola N.A."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Nicola N.A."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Willson T.A."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Willson T.A."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Rakar S."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Rakar S."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Begley C.G."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Begley C.G."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Harrison-Smith M."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Harrison-Smith M."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Raicevic A."xsd:string |
| http://purl.uniprot.org/citations/7957045 | http://purl.uniprot.org/core/author | "Raicevic A."xsd:string |