| http://purl.uniprot.org/citations/7957077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7957077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7957077 | http://www.w3.org/2000/01/rdf-schema#comment | "The mutant mouse strain Mpv17 carries a retroviral insert in its genome which inactivates the Mpv17 gene. At a young age these mice develop glomerulosclerosis and nephrotic syndrome which resembles human disease. We show here that the Mpv17 gene product is highly conserved and encodes a peroxisomal protein. Loss of the Mpv17 protein does not impair peroxisome biogenesis but instead leads to a reduced ability to produce reactive oxygen species (ROS). In turn, overproduction of the Mpv17 gene in transfected cells results in dramatically enhanced levels of intracellular ROS indicating a direct involvement of Mpv17 in ROS production. These data reveal a role for the Mpv17 protein in peroxisomal reactive oxygen metabolism and establish a novel link between peroxisomal ROS production and glomerulosclerosis."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06842.x"xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06842.x"xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Moll J."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Moll J."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Gorgas K."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Gorgas K."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Pfaff E."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Pfaff E."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Weiher H."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Weiher H."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Reuter A."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Reuter A."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Karasawa M."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Karasawa M."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Zwacka R.M."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/author | "Zwacka R.M."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/pages | "5129-5134"xsd:string |
| http://purl.uniprot.org/citations/7957077 | http://purl.uniprot.org/core/pages | "5129-5134"xsd:string |