| http://purl.uniprot.org/citations/7958970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7958970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7958970 | http://www.w3.org/2000/01/rdf-schema#comment | "In previous studies, we showed that interleukin-4 (IL-4) suppressed porcine (p) macrophage superoxide production and that the mechanism of suppression involved down-regulation of the superoxide-generating enzyme NADPH oxidase heavy-chain 91-kDa subunit mRNA (gp91-phox) expression. In order to examine the effect of IL-4 on expression of the gene encoding the porcine NADPH oxidase light-chain 22-kDa subunit (p22-phox), we cloned the p22-phox cDNA from a macrophage library. The p22-phox cDNA is 786 bp in length and contains a 576-bp open reading frame which predicts a primary translation product of 192 amino acids (aa). Comparison of the porcine and human 22-phox cDNAs showed a high degree of similarity between the two species in their nucleotide (85%) and deduced aa (83%) sequences. as well as in their hydropathy profiles. Notable features, including a high proline content and an iron-coordinating His94, are conserved in both the porcine and human 22-Phox. A single species of mRNA of about 1 kb was detected in macrophages. The mRNA levels remained unchanged in cells treated with lipopolysaccharide (LPS) or with IL-4 at various concentrations from 0-50 ng/ml. Prolonged treatment with LPS or IL-4 did not enhance the effect of these substances on p22-phox mRNA expression. The effect of IL-4 on p22-phox mRNA expression was also compared with another immunosuppressive cytokine, transforming growth factor-beta 1 (TGF beta 1). No change in mRNA expression was found in the cells with or without TGF beta 1 treatment. The results indicated that the heavy and light chains of NADPH oxidase are independently regulated by IL-4 in macrophages."xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(94)90714-5"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(94)90714-5"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/author | "Murtaugh M.P."xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/author | "Murtaugh M.P."xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/pages | "363-367"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/pages | "363-367"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/title | "Cloning and expression of the gene encoding the porcine NADPH oxidase light-chain subunit (p22-phox)."xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/title | "Cloning and expression of the gene encoding the porcine NADPH oxidase light-chain subunit (p22-phox)."xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/volume | "148"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://purl.uniprot.org/core/volume | "148"xsd:string |
| http://purl.uniprot.org/citations/7958970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7958970 |
| http://purl.uniprot.org/citations/7958970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7958970 |
| http://purl.uniprot.org/citations/7958970 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7958970 |
| http://purl.uniprot.org/citations/7958970 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7958970 |
| http://purl.uniprot.org/uniprot/P52650 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7958970 |
| http://purl.uniprot.org/uniprot/#_kb.P52650_up.isolatedFrom_tissue.568 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7958970 |