| http://purl.uniprot.org/citations/7961975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7961975 | http://www.w3.org/2000/01/rdf-schema#comment | "Although a role for the beta gamma-subunits of heterotrimeric G proteins (G beta gamma) in signal transduction by several cellular systems has been established, the structural features of cellular proteins interacting with G beta gamma have yet to be fully elucidated. The G beta gamma-binding region of beta-adrenergic receptor kinase (beta ARK), a cytosolic enzyme recruited to the membrane receptor substrate by G beta gamma, has been localized to the carboxyl terminus of the enzyme. Here, we demonstrate that the amino terminus of phosducin, a 33-kDa G beta gamma-binding retinal phosphoprotein, contains sequences homologous with the G beta gamma-binding domain of beta ARK. Accordingly, a glutathione S-transferase-fusion protein containing only the amino-terminal 105 amino acids of phosducin displayed G beta gamma binding ability. This domain of phosducin contains a protein kinase A (PKA) phosphorylation site, and upon phosphorylation, the binding of full-length phosducin to G beta gamma is reduced. In addition, transient expression of phosducin in COS-7 cells significantly inhibits G beta gamma-mediated phosphoinositide hydrolysis. This inhibitory effect is completely reversed by pretreatment of cells with dibutyryl cAMP, an activator of PKA. Thus, the binding of G beta gamma to phosducin can be regulated by PKA-phosphorylation in an intact cell model system."xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)43955-5"xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/author | "Touhara K."xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/author | "Inglese J."xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/author | "Kurose H."xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/author | "Hawes B.E."xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/pages | "29825-29830"xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/title | "Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling."xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://purl.uniprot.org/core/volume | "269"xsd:string |
| http://purl.uniprot.org/citations/7961975 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7961975 |
| http://purl.uniprot.org/citations/7961975 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7961975 |
| http://purl.uniprot.org/uniprot/P20941#attribution-8AA129BB5CE994C0FECFB7A960A3704A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7961975 |