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http://purl.uniprot.org/citations/7962047http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7962047http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7962047http://www.w3.org/2000/01/rdf-schema#comment"Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. To examine the molecular basis for the specification of centromeric chromatin, we have cloned a human cDNA that encodes the 17-kD histone-like centromere antigen, CENP-A. Two domains are evident in the 140 aa CENP-A polypeptide: a unique NH2-terminal domain and a 93-amino acid COOH-terminal domain that shares 62% identity with nucleosomal core protein, histone H3. An epitope tagged derivative of CENP-A was faithfully targeted to centromeres when expressed in a variety of animal cells and this targeting activity was shown to reside in the histone-like COOH-terminal domain of CENP-A. These data clearly indicate that the assembly of centromeres is driven, at least in part, by the incorporation of a novel core histone into centromeric chromatin."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.org/dc/terms/identifier"doi:10.1083/jcb.127.3.581"xsd:string
http://purl.uniprot.org/citations/7962047http://purl.org/dc/terms/identifier"doi:10.1083/jcb.127.3.581"xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/author"Sullivan K.F."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/author"Sullivan K.F."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/author"Hechenberger M."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/author"Hechenberger M."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/author"Masri K."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/author"Masri K."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/name"J. Cell Biol."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/name"J. Cell Biol."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/pages"581-592"xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/pages"581-592"xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/title"Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/title"Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere."xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/volume"127"xsd:string
http://purl.uniprot.org/citations/7962047http://purl.uniprot.org/core/volume"127"xsd:string
http://purl.uniprot.org/citations/7962047http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7962047
http://purl.uniprot.org/citations/7962047http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7962047
http://purl.uniprot.org/citations/7962047http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/7962047
http://purl.uniprot.org/citations/7962047http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/7962047