| http://purl.uniprot.org/citations/7963517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7963517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7963517 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the cloning and initial characterization of the mouse homologues of the bcl-2-related gene, bcl-x. We compare these to the two major isoforms of human bcl-x that were previously identified, bcl-xLong (bcl-xL) which has death repressor activity similar to bcl-2, and bcl-xShort (bcl-xS), an alternative mRNA splice product that deletes a highly conserved domain shared by bcl-2 family members and promotes cell death in transfection studies. In addition to murine (m) bcl-xL and mbcl-xS, we have cloned a novel cDNA isoform that we designate mbcl-x delta TM. This cDNA deletes, by means of alternative splicing, the carboxy terminal transmembrane domain of bcl-x and is predicted to be a soluble, rather than membrane-bound, protein. We found that mbcl-x mRNA is highly inducible in splenocytes stimulated with either anti-CD3 Abs or LPS/dextran sulfate, and that the major species of mbcl-x mRNA in a variety of cell lines and tissues was the xL isoform. Transfection of mbcl-xL or mbcl-xS into Hela cells resulted in targeting primarily to mitochondria, whereas mbcl-x delta TM localized diffusely throughout the cytosol. Overexpression of the novel delta TM isoform in an IL-3-dependent cell line delayed the onset of apoptosis induced by growth factor withdrawal. Thus, a naturally-occurring form of mbcl-x present in lymphocytes that does not localize to the mitochondrial membrane is functional in preventing apoptotic cell death. Moreover, these data suggest that bcl-x provides a life signal in activated lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Fang W."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Fang W."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Behrens T.W."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Behrens T.W."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Mueller D.L."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Mueller D.L."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Rivard J.J."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/author | "Rivard J.J."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/pages | "4388-4398"xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/pages | "4388-4398"xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/title | "Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/title | "Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/7963517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7963517 |
| http://purl.uniprot.org/citations/7963517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7963517 |
| http://purl.uniprot.org/citations/7963517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7963517 |
| http://purl.uniprot.org/citations/7963517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7963517 |