| http://purl.uniprot.org/citations/7964501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7964501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7964501 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine Ly-49 antigen belongs to a family of type II transmembrane molecules containing lectin-like domains. The original member of this family, Ly-49A, has been demonstrated to be expressed by a subpopulation of natural killer (NK) cells, bind certain class I major histocompatibility complexes (MHC), and act as a negative regulator of lytic activity. The expression patterns and functional activities of the other Ly-49s, however, is unknown. We extended the study of this family by isolating cDNAs encoding two new Ly-49 molecules. The reactivity of these and previously identified Ly-49 molecules with NK antibodies was tested in a COS cell expression system. YE1/32 and YE1/48 bound Ly-49A specifically, and 5E6 reacted only with Ly-49C. Three-color flow cytometric analysis demonstrated Ly-49A and Ly-49C expression defines complex, but distinct subsets within NK1.1+ cells. Some NK1.1-CD3+ as well as NK1.1-CD3-cells expressing Ly-49A or C were also detected. Analysis of MHC congenic strains of mice demonstrated that YE1/32+ and YE1/48+ NK cells are not deleted, as has been shown with the Ly-49A mAb A1. Furthermore, COS cells transfected with Ly-49A bound H-2d and H-2k cell lines, whereas Ly-49C transfectants bound H-2d, H-2k, H-2b, and H-2s. The antibodies 5E6 and 34-1-2S (anti-class I MHC) inhibited the binding of Ly-49C to an H-2s cell line. These results imply that the NK cell antigens Ly-49A and C bind to different repertoires of class I MHC molecules."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.180.6.2287"xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.180.6.2287"xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Takei F."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Takei F."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Brennan J."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Brennan J."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Jefferies W."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Jefferies W."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Mager D."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/author | "Mager D."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/pages | "2287-2295"xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/pages | "2287-2295"xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/title | "Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/title | "Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties."xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/7964501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7964501 |
| http://purl.uniprot.org/citations/7964501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7964501 |