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| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/7966560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7966560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7966560 | http://www.w3.org/2000/01/rdf-schema#comment | "In earlier studies, we have shown that superinfection of an interleukin-2 (IL-2)-dependent, Moloney murine leukemia virus (MoMuLV)-induced rat T-cell lymphoma line (4437A) with mink cell focus-forming (also called polytropic) murine retroviruses induces rapid progression to IL-2-independent growth. In this report, we present evidence that the vast majority (> 90%) of the IL-2-independent lines established from polytropic or xenotropic virus-infected 4437A cells carry provirus insertions in the 3' untranslated region of the IL-9 receptor gene (Gfi-2 [for growth factor independence-2]/IL-9R). Prior to superinfection, the cells express neither IL-9 nor IL-9R. Following superinfection and provirus insertion in the Gfi-2/IL-9R locus, the cells express high levels of mRNA transcripts with a truncated 3' untranslated region which are predicted to encode the normal IL-9R protein product. The same IL-2-independent cells also express IL-9 which is induced by an insertional mutagenesis-independent mechanism. The establishment of an IL-9-dependent autocrine loop was sufficient to render the cells IL-2 independent, as suggested by the finding that 4437A cells, expressing a stably transfected Gfi-2/IL-9R construct, do not require IL-2 when maintained in IL-9-containing media. Additional experiments designed on the basis of these results showed that IL-9 gene expression is induced rapidly following the infection of 4437A cells by polytropic or xenotropic viruses and occurs in the absence of selection for IL-2-independent growth. Taken together, these data suggest that infection of 4437A cells by mink cell focus-forming or xenotropic viruses induces the expression of IL-9, which in turn rapidly selects the cells expressing the IL-9 receptor through an insertional mutagenesis-dependent mechanism. Given that both the polytropic and xenotropic viruses can induce the IL-9-dependent autocrine loop, the reduced ability of the xenotropic viruses to rapidly induce IL-2 independence in culture and tumors in animals is likely to be the result of their lower growth rates."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.68.12.7709-7716.1994"xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/author | "Bear S.E."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/author | "Bear S.E."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/author | "Flubacher M.M."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/author | "Flubacher M.M."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/pages | "7709-7716"xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/pages | "7709-7716"xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/title | "Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/title | "Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/7966560 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7966560 |
| http://purl.uniprot.org/citations/7966560 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7966560 |
| http://purl.uniprot.org/citations/7966560 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7966560 |
| http://purl.uniprot.org/citations/7966560 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7966560 |
| http://purl.uniprot.org/uniprot/Q63216 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7966560 |