| http://purl.uniprot.org/citations/7972012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7972012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7972012 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase-related domains of unknown function are present in the JAK family of protein tyrosine kinases and in receptor/guanylyl cyclases. I used the yeast two-hybrid system to screen for proteins interacting with the kinase-like domain of the atrial natriuretic peptide (ANP) receptor/guanylyl cyclase. A yeast strain was constructed expressing a fusion of this kinase-like domain to the lexA DNA-binding domain and containing a HIS3 gene under the control of lexA upstream activating sequences. These yeast cells were transformed with a plasmid library of mouse embryo cDNA fragments fused to the VP16 transcriptional activation domain. Cells containing VP16-fusion proteins interacting with the lexA-kinase-like domain fusion protein were selected by growth in the absence of histidine. A partial-length cDNA clone isolated by using this approach encoded a protein that interacted specifically with the ANP-receptor protein kinase-like domain both in yeast cells and in vitro. Tissue-specific expression of a 2.2-kb mRNA hybridizing to this cDNA paralleled the known pattern of ANP-receptor mRNA expression. A full-length cDNA clone isolated from a rat lung library was predicted to encode a 55-kDa protein containing at its amino terminus a targeting domain that binds to the ANP-receptor kinase-like domain and containing at its carboxyl terminus a putative protein-serine phosphatase domain. This protein is a possible candidate for the phosphatase involved in desensitizing the ANP receptor. Targeting of regulatory proteins may be an important function of protein kinase-like domains."xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.23.11075"xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.23.11075"xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/author | "Chinkers M."xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/author | "Chinkers M."xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/pages | "11075-11079"xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/pages | "11075-11079"xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/title | "Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor."xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/title | "Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor."xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/7972012 | http://purl.uniprot.org/core/volume | "91"xsd:string |
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| http://purl.uniprot.org/citations/7972012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7972012 |
| http://purl.uniprot.org/citations/7972012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7972012 |
| http://purl.uniprot.org/uniprot/Q64538 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7972012 |
| http://purl.uniprot.org/embl-cds/AAB18613.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7972012 |
| http://purl.uniprot.org/uniprot/Q60676 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7972012 |
| http://purl.uniprot.org/uniprot/#_kb.Q64538_up.isolatedFrom_tissue.568 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7972012 |