| http://purl.uniprot.org/citations/7973658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7973658 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor beta.(IL-2R beta) and common gamma (gamma c) chains. Mutations of gamma c can result in X-linked severe combined immunodeficiency (XSCID). IL-2, IL-4, IL-7 (whose receptors are known to contain gamma c), and IL-9 (whose receptor is shown here to contain gamma c) induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases Jak1 and Jak3. Jak1 and Jak3 associated with IL-2R beta and gamma c, respectively; IL-2 induced Jak3-IL-2R beta and increased Jak3-gamma c associations. Truncations of gamma c, and a gamma c, point mutation causing moderate X-linked combined immunodeficiency (XCID), decreased gamma c-Jak3 association. Thus, gamma c mutations in at least some XSCID and XCID patients prevent normal Jak3 activation, suggesting that mutations of Jak3 may result in an XSCID-like phenotype."xsd:string |
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| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Berg M."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Noguchi M."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Johnston J.A."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Kawamura M."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Witthuhn B.A."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "McVicar D.W."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Silvennoinen O."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Bacon C.M."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Russell S.M."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/author | "Friedmann M."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/pages | "1042-1045"xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/title | "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID."xsd:string |
| http://purl.uniprot.org/citations/7973658 | http://purl.uniprot.org/core/volume | "266"xsd:string |
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